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KMID : 0624620120450020079
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BMB Reports
2012 Volume.45 No. 2 p.79 ~ p.84
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RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction
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Jung In-Duk
Kim Hye-Young
Park Jin-Wook
Lee Chang-Min
Noh Kyung-Tae
Kang Hyun-Kyu
Heo Deok-Rim
Lee Su-Jung
Son Kwang-Hee
Park Hee-Ju
Shin Sung-Jae
Park Jong-Hwan
Ryu Seung-Wook
Park Yeong-Min
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Abstract
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In asthma, T helper 2 (TH2)-type cytokines such as interleukin (IL)-4, IL-5, and IL-13 are produced by activated CD4+ T cells. Dendritic cells played an important role in determining the fate of naive T cells into either TH1 or TH2 cells. We determined whether RG-II regulates the TH1/TH2 immune response by using an ovalbumin-induced murine model of asthma. RG-II reduced IL-4 production but increased interferon-gamma production, and inhibited GATA-3 gene expression. RG-II also inhibited asthmatic reactions including an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyperresponsiveness. This study provides evidence that RG-II plays a critical role in ameliorating the pathogenic process of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of RG-II in terms of its effects in a murine model of asthma.
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KEYWORD
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Asthma, GATA-3, Rhamnogalacturonan II (RG-II), T helper 2 (TH2), T-bet
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